Human TRAIL protein, His tag
- Article
- Human TRAIL protein, His tag
- Product Number
- GTX00068-PRO-10UG
- Supplier
- GeneTex
- Size
- 10 ug
- Description
- The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Growth Factors, Chemokines & Cytokines
- Application
- Func
- Conjugate
- Unconjugated
- Synonyms
- Apo-2 ligand; APO2L; Apo-2L; CD253; chemokine tumor necrosis factor ligand superfamily member 10; TL2; TNF-related apoptosis inducing ligand TRAIL; TNLG6A; TRAIL; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
- Unigene ID
- 8743
- Gene Symbols
- TNFSF10
- Shipping Temperature
- BLUE ICE
- Supplier URL
- Visit supplier product page
Size: 10 ug
290.00 CHF