Human CD40-Ligand (Animal Free)
Catalog Number: AF-310-02-50UG Size: 50 ug Product Group Proteins Category Proteins, Peptides & Inhibitors Description CD40, a member of the TNF receptor superfamily, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain. The soluble form of CD40L is an 18 kDa protein comprising the entire TNF homologous region of CD40L and is generated EClass No. 34160505 Manufacturer: Peprotech Synonym: CD154|CD40 antigen ligand|CD40 ligand|CD40L|CD40-L|gp39|hCD40L|HIGM1|IGM|IMD3|T-B cell-activating molecule|T-BAM|T-cell antigen Gp39|TNF-related activation protein|TNFSF5|TRAP|tumor necrosis factor (ligand) superfamily member 5 GeneSymbol: CD40LG MW 16.3 GeneID 959 Data Sheet: https://www.peprotech.com/recombinant-human-scd40-ligand-2
