Nitrooleic acid (OA-NO2) is formed by nitration of oleic acid from excessive nitric oxide during inflammation (nitrative stress). OA-NO2 is a potent signaling molecule which can activate numerous receptors including TRPA1 cation channels and PPARI³. 9(10)-Nitrooleic acid is a mixture of the 9-nitro and 10-nitro isomers which are formed in equal amounts in vivo.References1. P.S. Baker et al aoeFatty Acid Transduction of Nitric Oxide signalinga Journal of Biological Chemistry 2005 280 42464-42475,2. F.J. Schopfer et al aoeCovalent Peroxisome Proliferator-Activated Receptor Adduction By Nitro-Fatty Acida Journal of Biological Chemistry 2010 285 12321-12333.
