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Anti CD31 (Ms,Sw) from Rat (SZ...

Article
Anti CD31 (Ms,Sw) from Rat (SZ31) for mouse FFPE tissue
Product Number
DIA-310
Supplier
Dianova (Biozol)
Size
500 ul
Description
Antibody clone SZ31 is the first antibody which reacts specifically with murine CD31 in formalin-fixed paraffin-embedded tissue sections. Clone SZ31 shows no cross-reactivity to human CD31. Outstanding specificity of clone SZ31 has been confirmed in more than 200 citations (CiteAB). CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) is expressed constitutively on the surface of embryonic and adult endothelial cells. It is also expressed on cell surfaces of monocytes, neutrophils, platelets and certain T-cell subsets. It has been detected on bone marrow-derived hematopoetic stem cells and embryonic stem cells. Cluster of Differentiation 31 (CD31) is a 130kDa integral membrane glycoprotein and as a member of the immunoglobulin superfamily involved in the mediation of cell-to-cell adhesion. CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Studies have shown CD31 to be a superior marker in human angiogenesis, which reportedly predicts tumor recurrence. Pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were excluded. The clone SZ31 (Anti-CD31) eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.
Category
Antibodies
Product Group
Monoclonal Antibodies
Application
ICC, IF, IHC, IHC-Fr, IHC-P, WB
Host
Rat
Species reactivity
Mouse, Other Insect / Arthropod, Porcine
Conjugate
Unconjugated
Clone ID
SZ31
Immunogen
Murine amino acid fragment (amino acids 610-681 of mouse CD31)
Synonyms
C85791; Cd31; Pecam; PECAM-1; platelet endothelial cell adhesion molecule
Unigene ID
18613
Gene Symbols
Pecam1
Shipping Temperature
RT
Supplier URL
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