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Anti CD73 (Hu) from Mouse (KK3...

Article
Anti CD73 (Hu) from Mouse (KK3)
Product Number
DIA-KK3
Supplier
Dianova (Biozol)
Size
500 ul
Description
Clone KK3 has been developed and validated specifically for the immunohistochemical (IHC) detection of CD73 in routine FFPE human tissue specimen. Given the broad expression of ectonucleotidases and adenosine receptors, immunohisto-chemical (IHC) application of monoclonal antibody KK3 may help to develop a better understanding of cell- and tissue- specific roles. CD73 and CD39 are cell surface enzymes that catabolize the breakdown of extracellular ATP into adenosine. As ectonucleo-sidases they play important roles in maintaining tissue and immune homeostasis through interfering with the extracellular purigeneric pathway. Since several labs independently have demonstrated an immunosuppressive role of CD73-adenosine in cancer, the CD73-adenosine axis has emerged as one of the most promising therapeutic targets in immuno-oncology. Adenosine triphosphate (ATP) is the major source of energy for the cell. Malignant cells can release high levels of ATP (e.g. after damage by radiotherapy or chemotherapy). Extracellular ATP provokes inflammation by driving "purinergic signals&rsquo and plays a significant role in promoting anti-tumor responses. Many tumors express the ectonucleotidases CD39 and CD73 to scarve such proinflammatory mediators and generate immunosuppressive adenosine nucleosides.
Category
Antibodies
Product Group
Monoclonal Antibodies
Application
IHC, IHC-P, WB
Host
Mouse
Species reactivity
Human
Conjugate
Unconjugated
Clone ID
KK3
Immunogen
Recombinant peptide of human CD73
Synonyms
5'-NT; 5'-nucleotidase; CALJA; CD73; E5NT; ecto-5'-nucleotidase; eN; eNT; NT; NT5; NTE; Purine 5-Prime-Nucleotidase
Unigene ID
4907
Gene Symbols
NT5E
Shipping Temperature
RT
Supplier URL
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