Anti DNA-RNA Hybrid Antibody(S...
- Article
- Anti DNA-RNA Hybrid Antibody(S9.6)
- Product Number
- RGK60001
- Supplier
- Antibody System
- Size
- 100 ug
- Description
- DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. A locus forming an DNA:RNA creates a double-stranded A/B intermediate conformation, with a second target for single-stranded nucleic acid binding proteins on the complementary, displaced DNA strand. They are shown to be resistant to the activity of DNA methyltransferases. The formation of DNA:RNA hybrids has been associated with a number of neurological diseases. Mutations in the DNA:RNA helicase senataxin (SETX) are implicated in the dominant juvenile form of amyotrophic lateral sclerosis type 4 and a recessive form of ataxia oculomotor apraxia type 2.
- Category
- Antibodies
- Product Group
- Monoclonal Antibodies
- Application
- ChIP, DB, EMSA, FISH, ICC, IF, IP, SPR
- Host
- Mouse
- Species reactivity
- Other
- Clone ID
- S9.6
- Purity
- >95%
- Formulation
- 0.01M PBS, pH 7.4.