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Anti IDH1 R132H (Hu) from Mous...

Article
Anti IDH1 R132H (Hu) from Mouse (H09)
Product Number
DIA-H09
Supplier
Dianova (Biozol)
Size
500 ul
Description
Antibody clone H09 reacts specifically with the isocitrate dehydrogenase 1 (IDH1) R132H point mutation in tissue sections from formalin-fixed brain tumor. Heterozygous point mutations of IDH1 codon 132 are frequent in World Health Organization (WHO) grade II and III gliomas. IDH1 R132H mutations occur in approximately 70% of astrocytomas and oligodendroglial tumors. The high frequency and distribution of the IDH1 R132H mutation among specific brain tumor entities allow the highly sensitive and specific discrimination of various tumors by immunohistochemistry, such as anaplastic astrocytoma from primary glioblastoma or diffuse astrocytoma WHO grade II from pilocytic astrocytoma or ependymoma. Noteworthy is the discrimination of the infiltrating edge of tumors with IDH1 mutation from reactive gliosis. Intented use / regulatory status: For in Vitro Diagnostic Use (Europe) / For Research Use only (All other countries)
Category
Antibodies
Product Group
Monoclonal Antibodies
Application
ICC, IHC, IHC-P, WB
Host
Mouse
Species reactivity
Human
Conjugate
Unconjugated
Clone ID
H09
Immunogen
Synthetic peptide, amino acid sequence CKPIIIGHHAYGD
Synonyms
epididymis luminal protein 216; epididymis secretory protein Li 26; epididymis secretory sperm binding protein; HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase [NADP] cytoplasmic; isocitrate dehydrogenase 1 (NADP+), soluble; NADP(+)-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; oxalosuccinate decarboxylase; PICD; Cytosolic NADP-isocitrate dehydrogenase
Unigene ID
3417
Gene Symbols
IDH1
Shipping Temperature
RT
Supplier URL
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