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Collagen Type II Antibody

Article
Collagen Type II Antibody
Product Number
600-401-104-0.5
Supplier
Rockland Immunochemicals
Size
500 ug
Description
Rockland produces highly active antibodies and conjugates to collagens. Collagens are highly conserved throughout evolution and are characterized by an uninterrupted ''Glycine-X-Y'' triplet repeat that is a necessary part of the triple helical structure. For these reasons, it is often extremely difficult to generate antibodies with specificities to collagens. The development of 'type' specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. Rockland extensively purifies collagens for immunization from human and bovine placenta and cartilage by limited pepsin digestion and selective salt precipitation. This preparation results in a native conformation of the protein. Antibodies are isolated from rabbit antiserum and are extensively cross-adsorbed by immunoaffinity purification to produce 'type' specific antibodies. Greatly diminished reactivity and selectivity of these antibodies will result if denaturing and reducing conditions are used for SDS-PAGE and immunoblotting. Ideal for investigators involved in Cell Biology, Signal Transduction and Stem Cell research.
Category
Antibodies
Product Group
Polyclonal Antibodies
Application
DB, ELISA, IF, IHC, IP, Multiplex Assay, WB
Host
Rabbit
Species reactivity
Bovine, Human, Other Mammal
Conjugate
Unconjugated
Formulation
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Immunogen
Collagen Type II from human knee cartilage and bovine nasal cartilage.
Synonyms
alpha-1 type II collagen; ANFH; AOM; arthroophthalmopathy, progressive (Stickler syndrome); cartilage collagen; chondrocalcin; COL11A3; collagen alpha-1(II) chain; collagen II, alpha-1 polypeptide; collagen, type II, alpha 1; SEDC; STL1
Unigene ID
1280
Gene Symbols
COL2A1
Shipping Temperature
BLUE ICE
Supplier URL
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