Phosphatidylinositol 4 5-bisphosphate diC8 (PI(4 5)P2 diC8) is a synthetic purified dioctanoyl PI(4 5)P2.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol 4 5-bisphosphate (PIP2) has been shown to play a central role in a variety of cellular functions. Amongst its many functions PIP2 is a substrate for Phospholipase C-coupled G-protein pathways involved in intracellular calcium release in a number of tissues and is also a substrate for class I phosphoinositide 3-kinase (PI3-K).Alternate Names: D-myo-Phosphatidylinositol 4 5-bisphosphate Dioctanoyl Phosphatidylinositol 4 5-bisphosphate PtdIns(4 5)P2 C8 PI(4 5)P2 C8 or PIP2Bulk discounts available please email echelon@echelon-inc.com for information.Publications Powered by Bioz See more details on Bioz1) Jenco J. M. A. Rawlingson et al. (1998). "Regulation of phospholipase D2: selective inhibition of mammalian phospholipase D isoenzymes by alpha- and beta-synucleins." Biochemistry 37(14): 4901-9.2) Campbell R. B. F. Liu et al. (2003). "Allosteric activation of PTEN phosphatase by phosphatidylinositol 4 5-bisphosphate." J Biol Chem 278(36): 33617-20.3) Haider S. A. I. Tarasov et al. (2007). "Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis." EMBO J 26(16): 3749.4) Lewis A. E. L. Sommer et al. (2011). "Identification of nuclear phosphatidylinositol 4 5-bisphosphate-interacting proteins by neomycin extraction." Mol Cell Proteomics 10(2): M110 003376.
