anti Myelin Basic Protein anti...
- Article
- anti Myelin Basic Protein antibody [7D2]
- Product Number
- ARG10722-50UL
- Supplier
- Arigo Biolaboratories
- Size
- 50 ul
- Description
- The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
- Category
- Antibodies
- Product Group
- Monoclonal Antibodies
- Application
- ICC, IF, IHC-Fr, WB
- Host
- Mouse
- Species reactivity
- Bovine, Chicken, Horse, Human, Mouse, Porcine, Rat
- Conjugate
- Unconjugated
- Clone ID
- 7D2
- Formulation
- Ascites fluid.
- Immunogen
- Purified myelin basic protein isolated from cow nerve.
- Synonyms
- 20 kDa microtubule-stabilizing protein; microtubule-stabilizing protein; myelin A1 protein; myelin basic protein
- Unigene ID
- 618684
- Gene Symbols
- MBP
- Shipping Temperature
- BLUE ICE
- Supplier URL
- Visit supplier product page
![Immunocytochemistry: Rat mixed neuron / glial cultures stained with ARG10722 anti-Myelin Basic Protein antibody [7D2] (red) and co-stained with chicken antibody to neurofilament NF-L (green). Blue is a DNA stain. Note that the MBP antibody stains an oligodendrocyte and some membrane shed from this cell. Other cells in the field include neurons, astrocytes, microglia and fibroblasts, all of which are completely negative for MBP, though the neuronal processes can be seen with the NF-L antibody.](http://www.arigobio.com/files/product/12527/ARG10722_ICC_1.jpg)
Size: 50 ul
479.00 CHF