APOPCYTO Caspase-3 Colorimetri...
- Article
- APOPCYTO Caspase-3 Colorimetric Assay Kit
- Product Number
- 4800
- Supplier
- MBL International
- Size
- 100 assays
- Description
- Caspases are members of the cysteine aspartic acid-specific protease family, which may be activated by a variety of signals including death receptor ligation, DNA damage, serum starvation, stress, and many more. Active caspases recognize a wide number of different substrates, leading to the activation of several different apoptotic pathways. For example, CAD (caspase-activated deoxyribonuclease), a protein involved in chromatin fragmentation into nucleosome units, is indirectly activated by caspase-3, while ICAD (inhibitor of caspase-activated deoxyribonuclease) is inactivated by caspase-3. The cleavage of several structural proteins by caspases leads to the unique apoptosis cell morphology of chromatin condensation, nucleus fragmentation and cytoplasmic integrity. Detection of caspase activity is recognized as a standard method to measure apoptosis activity. The most common method to measure caspase activity is via the fluorometric or colorimetric detection of the cleavage of caspase-specific substrates.
- Category
- Assay Kits
- Product Group
- Cellular Assays
- Synonyms
- A830040C14Rik; AC-; AC-3; apopain; Casp; CASP-3; caspase 3, apoptosis related cysteine protease; caspase-3; CC3; CPP; CPP32; CPP-32; cysteine protease CPP32; Lice; mld; mldy; protein Yama; SCA-1; SREBP cleavage activity 1; Ya; Yama; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; CPP32B; PARP cleavage protease; procaspase3
- Unigene ID
- 12367
- Gene Symbols
- Casp3
- Shipping Temperature
- DRY ICE
- Supplier URL
- Visit supplier product page