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APOPCYTO Caspase-3 Colorimetri...

Article
APOPCYTO Caspase-3 Colorimetric Assay Kit
Product Number
4800
Supplier
MBL International
Size
100 assays
Description
Caspases are members of the cysteine aspartic acid-specific protease family, which may be activated by a variety of signals including death receptor ligation, DNA damage, serum starvation, stress, and many more. Active caspases recognize a wide number of different substrates, leading to the activation of several different apoptotic pathways. For example, CAD (caspase-activated deoxyribonuclease), a protein involved in chromatin fragmentation into nucleosome units, is indirectly activated by caspase-3, while ICAD (inhibitor of caspase-activated deoxyribonuclease) is inactivated by caspase-3. The cleavage of several structural proteins by caspases leads to the unique apoptosis cell morphology of chromatin condensation, nucleus fragmentation and cytoplasmic integrity. Detection of caspase activity is recognized as a standard method to measure apoptosis activity. The most common method to measure caspase activity is via the fluorometric or colorimetric detection of the cleavage of caspase-specific substrates.
Category
Assay Kits
Product Group
Cellular Assays
Synonyms
apopain; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP32; CPP-32; CPP32B; cysteine protease CPP32; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1; A830040C14Rik; AC-; AC-3; Casp; caspase 3, apoptosis related cysteine protease; CC3; CPP; Lice; mld; mldy; Ya; Yama
Unigene ID
836
Gene Symbols
CASP3
Shipping Temperature
DRY ICE
Supplier URL
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