APOPCYTO Caspase-8 Colorimetri...
- Article
- APOPCYTO Caspase-8 Colorimetric Assay Kit
- Product Number
- 4805
- Supplier
- MBL International
- Size
- 100 assays
- Description
- Caspases are members of the cysteine aspartic acid-specific protease family, which may be activated by a variety of signals including death receptor ligation, DNA damage, serum starvation, stress, and many more. Active caspases recognize a wide number of different substrates, leading to the activation of several different apoptotic pathways. For example, CAD (caspase-activated deoxyribonuclease), a protein involved in chromatin fragmentation into nucleosome units, is indirectly activated by caspase-3, while ICAD (inhibitor of caspase-activated deoxyribonuclease) is inactivated by caspase-3. The cleavage of several structural proteins by caspases leads to the unique apoptosis cell morphology of chromatin condensation, nucleus fragmentation and cytoplasmic integrity. Detection of caspase activity is recognized as a standard method to measure apoptosis activity. The most common method to measure caspase activity is via the fluorometric or colorimetric detection of the cleavage of caspase-specific substrates.
- Category
- Assay Kits
- Product Group
- Cellular Assays
- Synonyms
- Casp; CASP-8; caspase-8; Fas-linked ICE-like protease; FLI; FLICE; MAC; MACH; Mch5; AIADK; CARD7; caspase recruitment domain protein 7; caspase recruitment domain-containing protein 7; CIDED; CLR17.1; death effector filament-forming Ced-4-like apoptosis protein; DEFCAP; DEFCAP-L/S; JRRP; MSPC; NAC; NACHT, leucine rich repeat and PYD (pyrin domain) containing 1; NACHT, leucine rich repeat and PYD containing 1; NACHT, LRR and PYD containing protein 1; NACHT, LRR and PYD domains-containing protein 1; NALP1; nucleotide-binding domain and caspase recruitment domain; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 1; PP1044; SLEV1; VAMAS1
- Unigene ID
- 12370
- Gene Symbols
- Casp8
- Shipping Temperature
- DRY ICE
- Supplier URL
- Visit supplier product page