AMSH (Associated Molecule with the SH3-domain of STAM) is a JAMM domain-containing protein that regulates receptor endosomal sorting of the epidermal growth factor receptor (EGFR)1. Recombinant AMSH functions as a deubiquitylase in vitro and ablation of AMSH activity by incubation of cells with AMSH siRNA enhances the degradation of EGFR1. AMSH mediated cleavage of K63 linked ubiquitin chains is enhanced in the presence of its binding partner STAM2.
Category
Antibodies
Product Group
Polyclonal Antibodies
Application
WB
Host
Chicken/Avian
Species reactivity
Human
Synonyms
AMSH; associated molecule with the SH3 domain of STAM; endosome-associated ubiquitin isopeptidase; MICCAP; STAM-binding protein; testicular secretory protein Li 54
