Anti Beta Catenin Antibody
- Article
- Anti Beta Catenin Antibody
- Product Number
- 0407-16
- Supplier
- Huabio
- Size
- 100 ul
- Description
- Key downstream component of the canonical Wnt signaling pathway In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.
- Category
- Antibodies
- Product Group
- Polyclonal Antibodies
- Application
- IF, IHC-P, WB
- Host
- Rabbit
- Species reactivity
- Human, Mouse, Rat, Zebrafish
- Conjugate
- Unconjugated
- Immunogen
- Synthetic peptide within N-terminal human beta Catenin.
- Molecular Weight
- 85 kDa
- Synonyms
- armadillo; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1; CTNNB; EVR7; MRD19; NEDSDV; beta-catenin; Bfc; Cat; Catnb; Mesc; catenin (cadherin associated protein), beta 1, 88kDa
- Unigene ID
- 1499
- Gene Symbols
- CTNNB1
- Shipping Temperature
- BLUE ICE
- Supplier URL
- Visit supplier product page
Size: 100 ul
389.00 CHF