Anti CD3 e (Ms,Hu,Mo,Ho,Bo,Sw,...
- Article
- Anti CD3 e (Ms,Hu,Mo,Ho,Bo,Sw,Rb,Dg,Ca,Mm,Ck,Bi,Fr) from Rat (HH3E) for FFPE tissues
- Product Number
- DIA-303
- Supplier
- Dianova (Biozol)
- Size
- 100 ul
- Description
- Antibody clone HH3E has been validated specifically for the detection of murine CD3 in formalin-fixed paraffin-embedded tissue sections (mouse FFPE). It detects a conserved epitope on the CD3 epsilon chain in a broad variety of species. CD3 is a defining feature of cells belonging to the T cell lineage and can therefore be used as T cell marker. Cluster of differentiation 3 (CD3) is composed of four distinct polypeptide chains CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta, that form a multimeric protein complex. The CD3 complex associates non-covalently with the T cell receptor (TCR) and serves as a T cell co-receptor. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. During T cell maturation the expression of CD3 migrates from the cytoplasm of pro-thymocytes to the cell-membrane of thymocytes. The specific appearance at all stages of T cell development make CD3 an ideal marker for normal T cells and T cell neoplasms (lymphomas, leukemias). Moreover, CD3 is a useful immunohistochemical marker for T cells in tissue sections. In a clinical setting in humans, CD3 serves as an important T cell marker for the classification of malignant lymphomas and leukemias. It can also be used to detect T cells in coeliac disease, lymphocytic and collagenous colitis. An anti-CD3 epsilon anti-body (Okt3) has been clinically approved for the induction of immunosuppression in organ transplantation. In animal studies anti-CD3 antibodies can induce tolerance to allografts.
- Category
- Antibodies
- Product Group
- Monoclonal Antibodies
- Application
- ICC, IF, IHC, IHC-Fr, IHC-P, WB
- Host
- Rat
- Species reactivity
- Bovine, Cat, Chicken, Dog, Horse, Human, Mouse, Non-human Primate, Other Amphibian, Other Avian, Other Insect / Arthropod, Other Mammal, Porcine, Rabbit
- Conjugate
- Unconjugated
- Clone ID
- HH3E
- Immunogen
- Synthetic peptide from cytoplasmic epitope of CD3: ERPPPVPNPDYEPC
- Synonyms
- CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3-epsilon; IMD18; T3E; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; TCRE; AI504783; CD3; CD3epsilon
- Unigene ID
- 916
- Gene Symbols
- CD3E
- Shipping Temperature
- RT
- Supplier URL
- Visit supplier product page