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Anti EGFR Antibody

Article
Anti EGFR Antibody
Product Number
0407-21
Supplier
Huabio
Size
100 ul
Description
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascad.
Category
Antibodies
Product Group
Polyclonal Antibodies
Application
IF, IHC-P, WB
Host
Rabbit
Species reactivity
Human, Mouse, Rat
Conjugate
Unconjugated
Immunogen
Synthetic peptide within mouse EGFR aa 11-60 / 1,210.
Molecular Weight
Predicted band size: 134 kDa
Synonyms
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; epidermal growth factor receptor; epidermal growth factor receptor tyrosine kinase domain; ERBB; ERBB1; erb-b2 receptor tyrosine kinase 1; ERRP; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1
Unigene ID
1956
Gene Symbols
EGFR
Shipping Temperature
BLUE ICE
Supplier URL
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