Anti p53 (Hu) from Mouse (Clon...
- Article
- Anti p53 (Hu) from Mouse (Clone: CC53)
- Product Number
- DIA-530-P05
- Supplier
- Dianova (Biozol)
- Size
- 500 ul
- Description
- The p53 tumor suppressor gene has been found to contain mutations in over 50% of human cancers. Many mutations of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 immunostaining is of use in demonstrating accumulation of p53 protein, which occurs in a high frequency in a wide variety of transformed cells. Anti-p53 Tumor Suppressor Protein antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild form of p53. Positive nuclear staining with this antibody has been shown to be a negative prognostic factor in Breast carcinoma, Lung carcinoma, Colorectal, and Urothelial carcinoma. p53 positivity has also been used to differentiate Uterine serous carcinoma from endometrioid carcinoma as well as to detect Intratubular germ cell neoplasia. Moreover antibody clone CC53 helps to detect single invading astrocytoma-cells.
- Category
- Antibodies
- Product Group
- Monoclonal Antibodies
- Application
- ICC, IHC, IHC-P, WB
- Host
- Mouse
- Species reactivity
- Human
- Conjugate
- Unconjugated
- Clone ID
- CC53
- Immunogen
- Recombinant human wild type p53 protein
- Synonyms
- antigen NY-CO-13; BCC7; BMFS5; cellular tumor antigen p53; LFS1; mutant tumor protein 53; P53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; tumor protein 53; tumor supressor p53; Tumor suppressor p53
- Unigene ID
- 7157
- Gene Symbols
- TP53
- Shipping Temperature
- RT
- Supplier URL
- Visit supplier product page