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Bax (active monomer) Recombina...

Article
Bax (active monomer) Recombinant Antibody [6A7] (OAAV00078)
Product Number
OAAV00544-200UG
Supplier
Aviva Systems Biology
Size
200 ug
Description
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
Category
Antibodies
Product Group
Recombinant Antibodies
Application
IHC, IP, WB
Host
Mouse
Species reactivity
Human, Mouse, Rat
Clone ID
6A7
Formulation
PBS with 0.02% Proclin 300.
Immunogen
KLH conjugated to peptides corresponding to amino acids 3-16 of murine Bax (CGSGEQLGSGGPTSS), amino acids 3-16 of human Bax (CGSGEQPRGGGPTSS), and amino acids 12-24 shared by Bax from both species (CGPTSSEQIMKTGA).
Synonyms
apoptosis regulator BAX; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2-associated X protein omega; BCL2L4; bcl2-L-4; bcl-2-like protein 4
Unigene ID
581
Gene Symbols
BAX
Shipping Temperature
BLUE ICE
Supplier URL
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