Bax (active monomer) Recombina...
- Article
- Bax (active monomer) Recombinant Antibody [6A7] (OAAV00078)
- Product Number
- OAAV00544-200UG
- Supplier
- Aviva Systems Biology
- Size
- 200 ug
- Description
- Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
- Category
- Antibodies
- Product Group
- Recombinant Antibodies
- Application
- IHC, IP, WB
- Host
- Mouse
- Species reactivity
- Human, Mouse, Rat
- Clone ID
- 6A7
- Formulation
- PBS with 0.02% Proclin 300.
- Immunogen
- KLH conjugated to peptides corresponding to amino acids 3-16 of murine Bax (CGSGEQLGSGGPTSS), amino acids 3-16 of human Bax (CGSGEQPRGGGPTSS), and amino acids 12-24 shared by Bax from both species (CGPTSSEQIMKTGA).
- Synonyms
- apoptosis regulator BAX; Baxdelta2G9; Baxdelta2G9omega; Baxdelta2omega; BCL2 associated X protein; BCL2-associated X protein omega; BCL2L4; bcl2-L-4; bcl-2-like protein 4
- Unigene ID
- 581
- Gene Symbols
- BAX
- Shipping Temperature
- BLUE ICE
- Supplier URL
- Visit supplier product page