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Beta Catenin Rabbit Polyclonal...

Article
Beta Catenin Rabbit Polyclonal Antibody (0407-16)
Product Number
0407-16
Supplier
Huabio
Size
100 ul
Description
Key downstream component of the canonical Wnt signaling pathway In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling.
Category
Antibodies
Product Group
Polyclonal Antibodies
Application
ICC, IHC-P, WB
Host
Rabbit
Species reactivity
Human, Mouse, Rat, Zebrafish
Conjugate
Unconjugated
Immunogen
Synthetic peptide within N-terminal human beta Catenin.
Molecular Weight
85 kDa
Synonyms
armadillo; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1; CTNNB; EVR7; MRD19; NEDSDV; Beta-catenin
Unigene ID
1499
Gene Symbols
CTNNB1
Shipping Temperature
BLUE ICE
Supplier URL
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