CD3 epsilon Recombinant Antibo...
- Article
- CD3 epsilon Recombinant Antibody [145-2c11] (OAAV00069)
- Product Number
- OAAV00535-200UG
- Supplier
- Aviva Systems Biology
- Size
- 200 ug
- Description
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement (PubMed:19956738, PubMed:24899501). Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
- Category
- Antibodies
- Product Group
- Recombinant Antibodies
- Application
- Act, FC, IP, WB
- Host
- Mouse
- Species reactivity
- Mouse
- Clone ID
- 145-2c11
- Formulation
- PBS with 0.02% Proclin 300.
- Immunogen
- H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone.
- Synonyms
- AI504783; CD3; CD3epsilon; T3e; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain
- Unigene ID
- 12501
- Gene Symbols
- Cd3e
- Shipping Temperature
- BLUE ICE
- Supplier URL
- Visit supplier product page