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CD3 epsilon Recombinant Antibo...

Article
CD3 epsilon Recombinant Antibody [145-2c11] (OAAV00070)
Product Number
OAAV00536-200UG
Supplier
Aviva Systems Biology
Size
200 ug
Description
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement (PubMed:19956738, PubMed:24899501). Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
Category
Antibodies
Product Group
Recombinant Antibodies
Application
Act, FC, IP, WB
Host
Hamster
Species reactivity
Mouse
Clone ID
145-2c11
Formulation
PBS with 0.02% Proclin 300.
Immunogen
H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone.
Synonyms
AI504783; CD3; CD3epsilon; T3e; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain
Unigene ID
12501
Gene Symbols
Cd3e
Shipping Temperature
BLUE ICE
Supplier URL
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