Your cart
  • Your shopping cart is empty!

CD3 epsilon Recombinant Antibo...

Article
CD3 epsilon Recombinant Antibody [UCHT1] (OAAV00075)
Product Number
OAAV00541-200UG
Supplier
Aviva Systems Biology
Size
200 ug
Description
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).
Category
Antibodies
Product Group
Recombinant Antibodies
Application
FC, IHC
Host
Rabbit
Species reactivity
Human
Clone ID
UCHT1
Formulation
PBS with 0.02% Proclin 300.
Immunogen
Human infant thymocytes.
Synonyms
CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3-epsilon; IMD18; T3E; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; TCRE
Unigene ID
916
Gene Symbols
CD3E
Shipping Temperature
BLUE ICE
Supplier URL
Visit supplier product page

Main Menu

Account