CD73 Inhibitor Screening Kit
- Article
- CD73 Inhibitor Screening Kit
- Product Number
- EP-166-96TESTS
- Supplier
- Acro Biosystems
- Size
- 96 tests
- Description
- 5'-nucleotidase (5'-NT), also known as ecto-5'-nucleotidase or CD73 (cluster of differentiation 73), is an enzyme that is encoded by the NT5E gene. CD73 commonly serves to convert AMP to adenosine. Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP. Other forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate. Rare allelic variants are associated with a syndrome of adult-onset calcification of joints and arteries (CALJA) affecting the iliac, femoral, and tibial arteries reducing circulation in the legs and the joints of the hands and feet causing pain.
- Category
- Assay Kits
- Product Group
- Biochemical Assays
- Species reactivity
- Human
- Shipping Temperature
- RT
- Supplier URL
- Visit supplier product page
Size: 96 tests
792.00 CHF