The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Category
Antibodies
Product Group
Polyclonal Antibodies
Application
ICC, IF, WB
Host
Rabbit
Species reactivity
Human, Mouse
Conjugate
Unconjugated
Formulation
PBS, 50% Glycerol, 0.02% Sodium azide.
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-172 of human CDKN3 (NP_001124323.1).