EGFR Rabbit Polyclonal Antibod...

EGFR Rabbit Polyclonal Antibody

0407-21

Huabio

100 ul

Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascad.

Antibodies

Polyclonal Antibodies

IF, IHC-P, WB

Rabbit

Human, Mouse, Rat

Unconjugated

PBS

Synthetic peptide within mouse EGFR aa 11-60 / 1,210.

134 kDa

avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; epidermal growth factor receptor; epidermal growth factor receptor tyrosine kinase domain; ERBB; ERBB1; erb-b2 receptor tyrosine kinase 1; ERRP; HER1; mENA; NISBD2; PIG61; proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; 9030024J15Rik; AI552599; Erb; Err; Errb1; Wa; wa2; wa-2; Wa5; waved 2

1956

EGFR

BLUE ICE