This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Category
Antibodies
Product Group
Polyclonal Antibodies
Application
IHC-P, WB
Host
Rabbit
Species reactivity
Human, Mouse, Rat
Conjugate
Unconjugated
Formulation
PBS, 50% Glycerol, 0.02% Sodium azide.
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human GPI (NP_000166.2).