Human IgM protein
- Article
- Human IgM protein
- Product Number
- GTX01553-PRO-1MG
- Supplier
- GeneTex
- Size
- 1 mg
- Description
- Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD, MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010]
- Category
- Antibodies
- Product Group
- Immunoglobulins
- Conjugate
- Unconjugated
- Formulation
- 0.1M Tris Chloride pH8.0, 0.5M Sodium Chloride, 0.1% Sodium azide.
- Synonyms
- AGM1; constant region of heavy chain of IgM; immunoglobulin mu chain; MU; VH
- Unigene ID
- 3507
- Gene Symbols
- IGHM
- Shipping Temperature
- DRY ICE
- Supplier URL
- Visit supplier product page
Size: 1 mg
274.00 CHF