Human UCHL1 Antibody Pair
- Article
- Human UCHL1 Antibody Pair
- Product Number
- ES-024-1PAIR
- Supplier
- Absea
- Size
- 1 pair
- Description
- The UCHL1 gene provides instructions for making an enzyme called ubiquitin carboxyl-terminal esterase L1 (UCH-L1). This enzyme is found in nerve cells throughout the brain and is involved in the cell machinery that breaks down (degrades) unneeded proteins. Several functions of UCH-L1 have been proposed, including ubiquitin hydrolase activity, ubiquitin ligase activity, and stabilization of the mono-ubiquitin pool. Dysfunction of UCH-L1 has been reported in various neurodegenerative diseases. Specific mutations in the UCHL1 gene, such as I93M and E7A, have been linked to early-onset Parkinson's disease and other neurological disorders, likely due to disruption of the ubiquitin-proteasome system and accumulation of toxic protein aggregates. Overexpression of UCH-L1 has also been shown to affect Alzheimer's disease pathology by regulating amyloid-beta production. Overall, the proper function of UCH-L1 appears crucial for maintaining neuronal health and preventing the development of neurodegenerative diseases.
- Category
- Antibodies
- Product Group
- Antibody Sets & Arrays
- Application
- ELISA
- Host
- Mouse
- Species reactivity
- Human
- Purity
- ≥85%
- Formulation
- phosphate buffered saline
- Shipping Temperature
- BLUE ICE
- Supplier URL
- Visit supplier product page
![Microtiter wells were coated with K52010_11G12 at 3 µg/mL as the capture antibody. Recommbinant UCHL1 protein (Cat #: PP-145) was used as the antigen. UCHL1 Antibody [K49007_1G1] was used as the detection antibody. Result: K52010_11G12 and K49007_1G1 can be used as a matched antibody pair to detect and quantify the concentration of Human UCHL1 with high specificity.](https://www.absea.bio/product-images/ES-024_Sandwich ELISA_10.jpg?v=0.24689876966535418)
Size: 1 pair
1'180.00 CHF