Shh antibody [5H4]

Article: Shh antibody [5H4]
Product Number: GTX60606-100UG
Supplier: GeneTex
Size: 100 ug
Description: This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right
Category: Antibodies
Product Group: Monoclonal Antibodies
Application: ELISA, FACS, IHC-P, WB
Host: Mouse
Species reactivity: Human, Mouse, Non-human Primate
Conjugate: Unconjugated
Clone ID: 5H4
Formulation: PBS, 0.05% Sodium azide.
Immunogen: Purified recombinant fragment of human SHH (AA: 26-161) expressed in E. Coli.
Synonyms: HHG1; HLP3; HPE3; MCOPCB5; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; SMMCI; sonic hedgehog homolog; sonic hedgehog protein; TPT; TPTPS; HHG-1
Unigene ID: 6469
Gene Symbols: SHH
Shipping Temperature: BLUE ICE
Supplier URL: Visit supplier product page

Size: 100 ug

571.00 CHF

Shh antibody [5H4]

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