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Shh antibody [5H4]

Article
Shh antibody [5H4]
Product Number
GTX60606-100UG
Supplier
GeneTex
Size
100 ug
Description
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved, the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right
Category
Antibodies
Product Group
Monoclonal Antibodies
Application
ELISA, FACS, IHC-P, WB
Host
Mouse
Species reactivity
Human, Mouse, Non-human Primate
Conjugate
Unconjugated
Clone ID
5H4
Formulation
PBS, 0.05% Sodium azide.
Immunogen
Purified recombinant fragment of human SHH (AA: 26-161) expressed in E. Coli.
Synonyms
HHG1; HLP3; HPE3; MCOPCB5; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; SMMCI; sonic hedgehog homolog; sonic hedgehog protein; TPT; TPTPS; HHG-1
Unigene ID
6469
Gene Symbols
SHH
Shipping Temperature
BLUE ICE
Supplier URL
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