TNFAIP3 Recombinant Rabbit Mon...
- Article
- TNFAIP3 Recombinant Rabbit Monoclonal Antibody [SN07-31]
- Product Number
- ET1611-40
- Supplier
- Huabio
- Size
- 100 ul
- Description
- A20 is a Cys2/Cys2 zinc finger protein that is induced by a variety of inflammatory stimuli and regulates gene expression. Specifically, A20 is induced by tumor necrosis factor (TNF) and interleukin 1 (IL-1), and acts as a negative regulator of nuclear factor κ B (NFκB) gene expression. By inhibiting NFκB activation, A20 plays a critical role in terminating NFκB responses to various stimuli. Although the C-terminal region of A20 contains seven zinc finger domains, only four of these domains are required for in vitro inhibition of TNF-induced NFκB activation. A20 also interacts with several other proteins, such as TRAF2, TRAF6 and IκB kinase (IKK) γ protein, and can thereby inhibit cell death. TXBP151, a novel A20-binding protein, may mediate the anti-apoptotic activity of A20. Involved in the negative feedback regulation of signal transduction, A20 and A20-binding proteins may be useful as novel therapeutic tools in the treatment of a variety of diseases.
- Category
- Antibodies
- Product Group
- Recombinant Antibodies
- Application
- FC, IF, IHC-P, WB
- Host
- Rabbit
- Species reactivity
- Human
- Conjugate
- Unconjugated
- Clone ID
- SN07-31
- Formulation
- TBS
- Immunogen
- Synthetic peptide within Human TNFAIP3 aa 491-540 / 790.
- Molecular Weight
- 90 kDa
- Synonyms
- A20; AISBL; OTU domain-containing protein 7C; OTUD7C; putative DNA-binding protein A20; TNFA1P2; tumor necrosis factor alpha-induced protein 3; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; zinc finger protein A20
- Unigene ID
- 7128
- Gene Symbols
- TNFAIP3
- Shipping Temperature
- BLUE ICE
- Supplier URL
- Visit supplier product page
Size: 100 ul
470.00 CHF