This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. [provided by RefSeq, Jul 2008]
Category
Proteins, Peptides and Small Molecules
Product Group
Peptides
Synonyms
hVPS35; maternal-embryonic 3; MEM3; PARK17; vacuolar protein sorting 35 homolog; vacuolar protein sorting-associated protein 35
