This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Category
Antibodies
Product Group
Monoclonal Antibodies
Application
ELISA
Host
Mouse
Species reactivity
Human
Conjugate
Unconjugated
Clone ID
S-21
Formulation
0.01M PBS (pH 7.2)
Immunogen
Purified recombinant human EGF, 6kDa, 53 amino acid residues
