erbB-2 (Her-2/neu) Recombinant...
- Article
- erbB-2 (Her-2/neu) Recombinant Antibody [4D5-8 (trastuzumab)] (OAAV00050)
- Product Number
- OAAV00533-200UG
- Supplier
- Aviva Systems Biology
- Size
- 200 ug
- Description
- Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
- Category
- Antibodies
- Product Group
- Recombinant Antibodies
- Application
- ELISA, FC, IHC
- Host
- Human
- Species reactivity
- Human
- Clone ID
- 4D5-8 (trastuzumab)
- Formulation
- PBS with 0.02% Proclin 300.
- Immunogen
- A431 cells (human epidermoid carcinoma) (over)expressing EGFR.
- Synonyms
- CD340; c-erb B2/neu protein; HER2; HER-2; HER-2/neu; herstatin; human epidermal growth factor receptor 2; metastatic lymph node gene 19 protein; MLN 19; NEU; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; NGL; proto-oncogene c-ErbB-2; proto-oncogene Neu; receptor tyrosine-protein kinase erbB-2; TKR1; tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog; VSCN2; p185erbB2
- Unigene ID
- 2064
- Gene Symbols
- ERBB2
- Shipping Temperature
- BLUE ICE
- Supplier URL
- Visit supplier product page