(S,S) Bisoleoyl-lysobisphospha...
- Article
- (S,S) Bisoleoyl-lysobisphosphatidic acid (LBPA)
- Product Number
- L-B181-100UG
- Supplier
- Echelon Biosciences
- Size
- 100 ug
- Description
- Lysobisphosphatidic acids (LBPAs), known also as bis-(monoacylglycerol)phosphates (BMPs) are specialized lipids reported to play a role in intracellular protein and lipid transport in healthy cells. Their accumulation was observed in pathologic liver tissue, and they also serve as antigens for auto-antibody generation in a human autoimmune condition termed antiphospholipid syndrome. Accumulation of LBPAs in intracellular, often multilamellar membranes is related to biomembrane polymorphism which may impact intracellular cholesterol transport. \n \n \n \n(S,S) Bisoleoyl-lysobisphosphatidic acid is the naturally occurring, biologically activie isomer of LPBA. \nSolubility \nMeOH:CHCl3 (1:1 v/v) > 1mg/mL \nStorage \n-20°C \nFeatured in Publications \n1) Abe, A, Shayman, J.A. (2009) "The role of negatively charged lipids in lysosomal phospholipase A2 function." Journal of Lipid Research. 50(10): 2027-35. \n2) Chevallier, J. et al. (2008) "Lysobisphosphatidic Acid Controls Endosomal Cholesterol Levels" Journal of Biological Chemistry. 283: 27871-27880 \n3) Yang, S-T. et al (2010) "Cell-Penetrating Peptide Induces Leaky Fusion of Liposomes Containing Late Endosome-Specific Anionic Lipid" Biophysical Journal. 8(20): 2525-2533 \n4) Alvira, D. et al. (2011) "Inhibition of Protein-tyrosine Phosphatase 1B (PTP1B) Mediates Ubiquitination and Degradation of Bcr-Abl Protein" Journal of Biological Chemistry. 286: 32313-32323. \n5) Bissig, C. et al. (2013) "Viral Infection Controlled by a Calcium-Dependent Lipid-Binding Module in ALIX" Cell. 25(4): 364-373. \n6) Baptist, M., et al. (2015). "2,2-Bis(monoacylglycero) PO4 (BMP), but Not 3,1-BMP, Increases Membrane Curvature Stress to Enhance I+/--Tocopherol Transfer Protein Binding to Membranes." Lipids January: 1-6. \n \n \n \nDocuments \nTechnical Data Sheet
- Category
- Lab Reagents & Chemicals
- Product Group
- Lipids
- Shipping Temperature
- BLUE ICE|DRY ICE
