7-Cl-O-Nec1
- Article
- 7-Cl-O-Nec1
- Product Number
- 10-4544-10MM(IN1MLDMSO)
- Supplier
- Focus Biomolecules
- Size
- 10 mM (in 1 ml DMSO)
- Description
- Necrostatin-1 analogue with superior potency (IC50 = 206nM vs 494nM), selectivity and metabolic stability in blocking RIP1.1,2 7-Cl-O-Nec-1 shows no off-target inhibition of indolamine-2,3-deoxygenase (IDO) in contrast to Necrostatin-1 (Nec-1).3,4 7-Cl-O-Nec-1 showed higher activity in inhibiting necroptosis in Jurkat cells than Necrostatin-1 (EC50 = 210 nM vs. EC50 = 490 nM), no non-specific cytotoxicity at high concentrations (100 µM) and reasonable pharmacokinetic characteristics when used in mice.2 7-Cl-O-Nec-1 is recommended for cellular and in vivo use over Necrostatin-1.5
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Inhibitors & Activators
- CAS Number
- 852391-15-2
- Purity
- 98%
- Molecular Weight
- 277.71
- Shipping Temperature
- RT
- Supplier URL
- Visit supplier product page
