Animal-Free Recombinant Human ...
- Article
- Animal-Free Recombinant Human BMP-2
- Product Number
- PC-AF-H-BMP2-250UG
- Supplier
- Pacific Coast Biologics
- Size
- 250 ug
- Description
- Bone Morphogenetic Proteins (BMPs) are part of the TGF-β superfamily, a group of structurally related signaling proteins. Among them, BMP-2 stands out as a potent osteoinductive cytokine, capable of prompting bone and cartilage formation when coupled with osteoconductive carriers like collagen and synthetic hydroxyapatite. Besides its role in osteogenesis, BMP-2 contributes significantly to cardiac morphogenesis and is expressed in various tissues such as the lung, spleen, brain, liver, prostate, ovary, and small intestine. The active form of BMP-2 is a 26 kDa protein made up of two identical 114 amino acid polypeptide chains connected by a single disulfide bond. Each BMP-2 monomer is part of a precursor polypeptide, featuring a 23 amino acid signal sequence for secretion and a 259 amino acid propeptide. Upon precursor dimerization, a furin-type protease cleaves the covalent bonds between the propeptide (also a disulfide-linked homodimer) and the mature BMP-2 ligand.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Growth Factors, Chemokines & Cytokines
- Purity
- ≥ 98% by SDS-PAGE gel and HPLC analyses
- Molecular Weight
- 26 kDa
- Synonyms
- BDA2; BMP2A; bone morphogenetic protein 2; bone morphogenetic protein 2A; SSFSC; SSFSC1
- Unigene ID
- 650
- Gene Symbols
- BMP2
- Supplier URL
- Visit supplier product page