Animal-Free Recombinant Human ...
- Article
- Animal-Free Recombinant Human GDNF
- Product Number
- AF-450-10-250UG
- Supplier
- Peprotech
- Size
- 250 ug
- Description
- GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Growth Factors, Chemokines & Cytokines
- Molecular Weight
- 30.4
- Synonyms
- astrocyte-derived trophic factor; ATF; ATF1; ATF2; glial cell line-derived neurotrophic factor; HFB1-GDNF; HSCR3
- Unigene ID
- 2668
- Gene Symbols
- GDNF
- Articlegroup
- Peprotech Bulk
- Shipping Temperature
- RT