Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM]
Category
Antibodies
Product Group
Polyclonal Antibodies
Application
WB
Host
Rabbit
Species reactivity
Human
Conjugate
Unconjugated
Formulation
PBS, 1% BSA, 20% Glycerol, 0.025% ProClin 300.
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Aurora B. The exact sequence is proprietary.
