A naturally-occurring anthraquinone with diverse effects, including the suppression of inflammation, dyslipidemia, and cancer, directly and selectively inhibits CK2 (IC50 = 0.89 µM) and the COP9 signalosome, acts as a phytoestrogen, blocking 17β-estradiol binding to ER with Ki values of 0.77 and 1.5 µM for ERα and ERβ, respectively
