HLA-A,B,C mAb (W6/32), InVivoP...
- Article
- HLA-A,B,C mAb (W6/32), InVivoPure
- Product Number
- AK3603P-25MG
- Supplier
- InVivo BioTech Services
- Size
- 25 mg
- Description
- The HLA-A,B,C mAb (W6/32) monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, C. MHC class I antigens associated with beta 2-microglobulin are expressed by all human nucleated cells and are central in cell-mediated immune response and tumor surveillance. W6/32 mAb recognizes a non-polymorphic epitope shared among products of the HLA-A, B, and C loci and immunoprecipitates both 43 kDa and 11-12 kDa chains. Crossreactivity is also seen in baboon, rhesus and cynomolgus monkey. MHC class I plays a crucial role in the adaptive immune response by presenting endogenous antigens to cytotoxic CD8 T cells. The T cell receptor (TCR)/CD3 complex of CD8 T cells interacts with peptide MHC class I, which induces CD8 T cell activation and subsequent cell killing. CD8 molecules also bind to MHC class I, which enhances TCR signaling. In contrast to CD8 T cells, MHC class I is an inhibitory ligand for natural killer cells (NK cells) and promotes self-tolerance.
- Category
- Antibodies
- Product Group
- Monoclonal Antibodies
- Application
- Func
- Host
- Mouse
- Species reactivity
- Human
- Clone ID
- W6/32
- Purity
- >=90%
- Formulation
- Clear Liquid, PBS, pH 7.4, 0.2 µm sterile filtered
- Immunogen
- Animals were immunized with cells from human tonsils. Spleen cells were fused with P3X63Ag8 myeloma cells
- Supplier URL
- Visit supplier product page