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HLA DP/DQ/DR mAb (IVA12), InVi...

Article
HLA DP/DQ/DR mAb (IVA12), InVivoPure
Product Number
AK3601P-25MG
Supplier
InVivo BioTech Services
Size
25 mg
Description
The clone IVA12 recognizes the shared epitopes of human leukocyte antigen (HLA) class II molecules HLA-DP, HLA-DQ and HLA-DR heterodimeric cell surface glycoproteins comprised of an α (heavy) chain and a β (light) chain. They are expressed on B cells, activated T cells, monocytes/macrophages, dendritic cells, and other non-professional antigen presenting cells (APCs). HLA-Class II expressing APCs specifically present antigens recognized by TCR/CD3 complex of CD4+ T cells. Reactive microglia and perivascular cells in multiple sclerosis lesions express all three types of HLA-Class II molecules, whereas microglia in the normal CNS express HLA-DR only.
Category
Antibodies
Product Group
Monoclonal Antibodies
Application
Blk
Host
Mouse
Species reactivity
Human
Clone ID
IVA12
Purity
≥ 90 % (CGE, reducing conditions) ≤ 10 % aggregates (analytical SEC) Endotoxin level ≤ 2 EU/mg
Formulation
Clear Liquid, PBS, pH 7.4, 0.2 µm sterile filtered
Immunogen
Animals were immunized with the Priess human B cell line
Supplier URL
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