RSPO1/R-spondin-1, Human (CHO,...
- Article
- RSPO1/R-spondin-1, Human (CHO, His)
- Product Number
- HY-P7114-100UG
- Supplier
- MedChemExpress
- Size
- 100 ug
- Description
- RSPO1/R-spondin-1 is a potent activator of the Wnt/β-catenin signaling pathway and a secretory glycoprotein belonging to the R-spondin family. RSPO1 homotetramers synergize with LRP5/6 via LGR4/5/6 and activate the Wnt/β-catenin pathway by inhibiting DKK1/Kremen-mediated LRP6 endocytosis. RSPO1 promotes β-catenin nuclear translocation, drives HSC activation in liver fibrosis, inhibits adipocyte thermogenic gene expression, and promotes intestinal epithelial proliferation[1][2][3][4]. RSPO1/R-spondin-1 Protein, Human (CHO, His) is a recombinant human RSPO1 protein expressed in CHO cells with a C-6*His tag.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Purity
- 98.0
- Molecular Weight
- Approximately 38-43.3 kDa, based on SDS-PAGE under reducing conditions.
- Synonyms
- CRISTIN3; roof plate-specific spondin-1; RSPO; R-spondin homolog; R-spondin-1
- Unigene ID
- 284654
- Gene Symbols
- RSPO1
- Shipping Temperature
- BLUE ICE