Recombinant Human Heregulinbet...
- Article
- Recombinant Human Heregulinbeta-1
- Product Number
- 100-03-500UG
- Supplier
- Peprotech
- Size
- 500 ug
- Description
- Neuregulin/Heregulin is a family of structurally-related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-beta1 contains an Ig domain and an EGF-like domain, the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-beta1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant Human Heregulinbeta-1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinbeta-1 (65 amino acid residues).
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Growth Factors, Chemokines & Cytokines
- Molecular Weight
- 7.5 kDa
- Synonyms
- acetylcholine receptor-inducing activity; ARIA; GGF; GGF2; glial growth factor 2; heregulin, alpha (45kD, ERBB2 p185-activator); HGL; HRG; HRG1; HRGA; MST131; MSTP131; NDF; neu differentiation factor; NRG1-IT2; pro-neuregulin-1, membrane-bound isoform; pro-NRG1; sensory and motor neuron derived factor; SMDF
- Unigene ID
- 3084
- Gene Symbols
- NRG1
- Articlegroup
- Peprotech Bulk
- Shipping Temperature
- RT