Recombinant Human IGF-BP5
- Article
- Recombinant Human IGF-BP5
- Product Number
- 100-05-5UG
- Supplier
- Peprotech
- Size
- 5 ug
- Description
- IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP5 is a 28.6 kDa, cysteine-rich, secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts, and osteoblasts. Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP-5-overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition, and retarded muscle development. Recombinant Human IGF-BP5 is a 28.6 kDa protein consisting of 253 amino acid residues.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Molecular Weight
- 28.6 kDa
- Synonyms
- IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; insulin-like growth factor-binding protein 5
- Unigene ID
- 3488
- Gene Symbols
- IGFBP5
- Articlegroup
- Peprotech Katalog
- Shipping Temperature
- RT