Recombinant Human Sonic Hedgeh...
- Article
- Recombinant Human Sonic Hedgehog (Shh)
- Product Number
- 100-45-01M
- Supplier
- Peprotech
- Size
- 2 x 500 ug
- Description
- Members of the Hedgehog (Hh) family are highly conserved proteins that are widely represented throughout the animal kingdom. The three known mammalian Hh proteins, Sonic (Shh), Desert (Dhh) and Indian (Ihh), are structurally related, and share a high degree of amino acid sequence identity (e.g. Shh and Ihh are 93% identical). The biologically active form of each Hh molecule is obtained by autocatalytic cleavage of their precursor proteins, and each corresponds to approximately one half of the N-terminal portion of the precursor molecule. Although Hh proteins have unique expression patterns and distinct biological roles within their respective regions of secretion, they use the same signaling pathway and can be substituted for one another in experimental systems. Recombinant E.coli-derived Human Sonic Hedgehog is a 20.0 kDa protein consisting of 176 amino acid residues, including an N-terminal Ile-Val-Ile sequence substituted for the naturally occurring, chemically modified, Cys residue.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Kinases & Other Enzymes
- Molecular Weight
- 20
- Synonyms
- HHG1; HLP3; HPE3; MCOPCB5; shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; ShhNC; SMMCI; sonic hedgehog homolog; sonic hedgehog protein; TPT; TPTPS; HHG-1
- Unigene ID
- 6469
- Gene Symbols
- SHH
- Articlegroup
- Peprotech Bulk
- Shipping Temperature
- RT