Recombinant Human sRANK Ligand...
- Article
- Recombinant Human sRANK Ligand (CHO derived)
- Product Number
- 310-01C-2UG
- Supplier
- Peprotech
- Size
- 2 ug
- Description
- RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naive T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK+ T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells,including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Human RANKL is reactive on murine cells. PeproTech's CHO cell-derived Recombinant Human sRANK Ligand is a 22.1 kDa polypeptide comprised of the TNF-homologous region of RANKL and a N-terminal His-tag.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Growth Factors, Chemokines & Cytokines
- Molecular Weight
- 22.1
- Synonyms
- CD254; hRANKL2; ODF; OPGL; OPTB2; osteoclast differentiation factor; osteoprotegerin ligand; RANKL; receptor activator of nuclear factor kappa B ligand; sOdf; TNF-related activation-induced cytokine; TNLG6B; TRANCE; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; tumor necrosis factor ligand superfamily member 11; tumor necrosis factor superfamily member 11; Receptor activator of nuclear factor kappa-B ligand
- Unigene ID
- 8600
- Gene Symbols
- TNFSF11
- Articlegroup
- Peprotech Katalog
- Shipping Temperature
- RT