Prototypical TZD antidiabetic agent. Potent and selective PPARγ agonist (Kd=43 nM).1,2 Clinically useful antihyperglycemc agent.3 Induces a brown fat gene program in subcutaneous white adipose tissue via activation of the PRDM16 protein.4 Induces differentiation of pluripotent stem cells into adipocytes.5
