SKF-96365 (hydrochloride)
- Article
- SKF-96365 (hydrochloride)
- Product Number
- HY-100001-5MG
- Supplier
- MedChemExpress
- Size
- 5 mg
- Description
- SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice. SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia[1][2][3][4][5].
- Category
- Lab Reagents & Chemicals
- Product Group
- Biochemicals
- CAS Number
- 130495-35-1
- Purity
- 99.93
- Molecular Weight
- 402.91
- Shipping Temperature
- RT
- Estimated Delivery Time:
- 5 Business Days