Stabilin-2, also known as Feel2, FEX2, FELE-2, FELL2, is a conserved class H scavenger receptors expressed by sinusoidal endothelial cells (ECs) in the liver, lymph nodes, spleen and bone marrow. Stabilin-2 is the major receptor for hyaluronan, blocking antibodies or genetic ablation of Stabilin-2 inhibits hyaluronan uptake and leads to increased systemic hyaluronan levels. Besides hyaluronan, Stabilin-2 also binds other glycosaminoglycans, including heparin. It is also involved in antisense oligonucleotide pharmacokinetics and nanoparticle uptake, and it controls Von Willebrandt factor-factor VIII complex half-life and immunogenicity. The antibody is suitable material for validation and was used in the following applications: IF, IHC staining of rat, mouse spleen or liver, FACS on stably full length mStab2 transfected HEK293 cells and in in-vivo blocking studies.
