Tau-441 (2N4R) P301S Mutant Fi...
- Article
- Tau-441 (2N4R) P301S Mutant Filaments
- Product Number
- SPR-463B
- Supplier
- StressMarq Biosciences
- Size
- 100 ug
- Description
- Tau protein, encoded by the MAPT gene (UniProt ID: P10636), is a microtubule-associated protein essential for maintaining neuronal structure and function. The full-length Tau-441 isoform (2N4R) contains two N-terminal inserts and four microtubule-binding repeats, representing the longest and most aggregation-prone variant expressed in the adult human brain. The P301S mutation, located within the microtubule-binding domain, significantly enhances Tau's propensity to misfold and assemble into filamentous aggregates. These mutant filaments recapitulate key pathological features of tauopathies, including Alzheimer's disease and frontotemporal dementia, where neurofibrillary tangles composed of hyperphosphorylated Tau disrupt neuronal integrity and function. Tau-441 P301S mutant filaments serve as a robust experimental model for studying the molecular mechanisms of Tau aggregation, seeding, and prion-like propagation. Their use in transgenic animal models and in vitro systems has advanced our understanding of Tau-induced neurotoxicity, synaptic dysfunction, and neuroinflammation. These filaments are also instrumental in preclinical drug development, enabling the screening of compounds that inhibit Tau aggregation, promote clearance, or block intercellular transmission. By closely mimicking human pathological Tau, Tau-441 P301S filaments provide a high-fidelity platform for biomarker discovery and therapeutic innovation in neurodegenerative disease research.
- Category
- Proteins, Peptides and Small Molecules
- Product Group
- Proteins
- Application
- Func, In Vivo Assay, SDS-PAGE, WB
- Purity
- >95%
- Formulation
- PBS pH 7.4, 5 mM DTT, 2 mM MgCl2
- Molecular Weight
- 45.84 kDa
- Synonyms
- DDPAC; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; MAPTL; microtubule-associated protein tau; MSTD; MTBT1; MTBT2; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; TAU; tau-40
- Unigene ID
- 4137
- Gene Symbols
- MAPT
- Shipping Temperature
- DRY ICE
- Estimated Delivery Time:
- 5 Business Days
- Supplier URL
- Visit supplier product page
